Psalm 6:8
(8) Depart from me.--After the night of sorrow comes the morning of revived faith and confidence, if not of joy. The poet can turn to address his maligners with the assurance that God has heard his prayer, which in his agony he poured out, as he feared at the time, into deaf and unsympathising ears.

Verse 8. - Depart from me, all ye workers of iniquity! Note the sudden change of tone, very characteristic of the Davidical psalms. The psalmist, having offered his prayer, is so certain of its acceptance that he at once turns upon his adversaries with words of reproach, and almost of menace. "Depart from me!" he exclaims; "get ye gone! do not dare any more to persecute me or plot against me! Your efforts are in vain." For the Lord hath heard the voice of my weeping. David speaks from an inward conviction. He knows that he has prayed sincerely and fervently. He is certain, therefore, that his prayer is heard and accepted.

6:8-10 What a sudden change is here! Having made his request known to God, the psalmist is confident that his sorrow will be turned into joy. By the workings of God's grace upon his heart, he knew his prayer was accepted, and did not doubt but it would, in due time, be answered. His prayers will be accepted, coming up out of the hands of Christ the Mediator. The word signifies prayer made to God, the righteous Judge, as the God of his righteousness, who would plead his cause, and right his wrongs. A believer, through the blood and righteousness of Christ, can go to God as a righteous God, and plead with him for pardon and cleansing, who is just and faithful to grant both. He prays for the conversion of his enemies, or foretells their ruin.Depart from me, all ye workers of iniquity,.... The psalmist being fully assured that God had heard his prayer, that he should recover from his disorder, or be delivered out of his calamities, whether corporeal or spiritual, has on a sudden a spring of joy, faith, and comfort; as sometimes there is a quick transition from comfortable to uncomfortable frames; see Psalm 30:7; so on the contrary, there is as quick a passage from uncomfortable to comfortable ones; see Lamentations 3:18; who may be called "workers of iniquity" See Gill on Psalm 5:5; and these were either his open enemies, as Saul and his men, or Absalom and the conspirators with him, whom he bids to cease from following and pursuing after him; or his secret ones, hypocritical courtiers, that were about him, who were wishing and hoping for his death. It is the lot of God's people to be among the workers of iniquity; Lot was among the Sodomites, David was in Meshech and in the tents of Kedar, Isaiah was among men of unclean lips; Christ's lily is among thorns, and his sheep among goats; and though in some respects a civil conversation with wicked men cannot be avoided, for then good men must needs go out of the world; yet as little company should be kept with them as can be, and no fellowship should be had with them in sinful practices, nor in superstitious worship; and though there will not be a full and final separation from them in the present state of things, there will be hereafter, when these very words will be used by David's antitype, the Lord Jesus Christ; not only to profane sinners, but to carnal professors of religion, who have herded themselves with the people of God, Matthew 25:41. The reason why the psalmist took heart and courage, and ordered his wicked persecutors, or sycophants, to be gone from him, was his assurance of being heard by the Lord;

for the Lord hath heard the voice of my weeping; referring to what is said Psalm 6:6; he had not only lifted up his voice in prayer, but he had wept and made supplication, as Jacob did, Hosea 12:4; sometimes God brings his people to the throne of grace weeping, and with supplications leads them, Jeremiah 31:9; and then hears their cry and answers them.

Psalm 6:7
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