However, from the beginning of creation, 'God made them male and female.'

Genesis 1:27
So God created man in His own image; in the image of God He created him; male and female He created them.

Genesis 5:2
Male and female He created them, and He blessed them. And in the day they were created, He called them "man."

Mark 13:19
For those will be days of tribulation unmatched from the beginning of God's creation until now, and never to be seen again.

Romans 1:20
For since the creation of the world God's invisible qualities, His eternal power and divine nature, have been clearly seen, being understood from His workmanship, so that men are without excuse.

2 Peter 3:4
"Where is the promise of His coming?" they will ask. "Ever since our fathers fell asleep, everything continues as it has from the beginning of creation."

But from the beginning of the creation God made them male and female.